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Cathleen Gonzales Selected Research

begacestat

11/2009Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
12/2008Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.

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Cathleen Gonzales Research Topics

Disease

9Alzheimer Disease (Alzheimer's Disease)
01/2018 - 06/2008
4Ischemia
12/2009 - 08/2003
1Hypopigmentation (Hypomelanosis)
01/2018
1Parkinson Disease (Parkinson's Disease)
01/2013
1Disease Progression
01/2013
1Neuroinflammatory Diseases
06/2012
1Atrophy
10/2010
1Cognitive Dysfunction
10/2010
1Inflammation (Inflammations)
10/2010
1Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
12/2009
1Traumatic Brain Injuries (Traumatic Brain Injury)
12/2009
1Brain Ischemia (Cerebral Ischemia)
12/2009
1Edema (Dropsy)
12/2009
1Infarction (Infarctions)
12/2009
1Brain Infarction
12/2009
1Stroke (Strokes)
12/2009
1Amyloid Plaque
11/2009
1Cerebral Amyloid Angiopathy (Congophilic Angiopathy)
11/2009
1Neurodegenerative Diseases (Neurodegenerative Disease)
02/2008
1Ischemic Stroke
02/2007
1Hypoxia (Hypoxemia)
01/2007
1Wiskott-Aldrich Syndrome
04/2003

Drug/Important Bio-Agent (IBA)

6Proteins (Proteins, Gene)FDA Link
01/2018 - 04/2003
5Amyloid Precursor Protein Secretases (beta-Secretase)IBA
12/2017 - 12/2008
4Amyloid (Amyloid Fibrils)IBA
01/2018 - 06/2008
3Amyloid beta-PeptidesIBA
10/2010 - 06/2008
2Pharmaceutical PreparationsIBA
01/2018 - 12/2009
2EnzymesIBA
01/2018 - 08/2003
2begacestatIBA
11/2009 - 12/2008
2CaspasesIBA
02/2008 - 08/2003
1Aspartic Acid ProteasesIBA
01/2018
1Cathepsin DIBA
01/2018
1PrionsIBA
01/2013
1alpha-SynucleinIBA
01/2013
1EicosanoidsIBA
06/2012
1EndocannabinoidsIBA
06/2012
1bosutinibIBA
12/2009
14- ((2,4- dichloro- 5- methoxyphenyl)amino)- 6- methoxy- 7- (4- (4- methypiperazin- 1- yl)but- 1- ynyl)- 3- quinolinecarbonitrileIBA
12/2009
1src-Family KinasesIBA
12/2009
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/2009
1SulfonamidesIBA
11/2009
1Peptides (Polypeptides)IBA
11/2009
1ThiophenesIBA
11/2009
1Apoptosis Regulatory ProteinsIBA
02/2007
1GABA-B ReceptorsIBA
01/2007
1Adenosine Monophosphate (AMP)IBA
01/2007
1SpectrinIBA
08/2003
1Caspase 3 (Caspase-3)IBA
08/2003
14-O-carboxymethylascochlorinIBA
08/2003
1Tissue ExtractsIBA
08/2003
1acetyl- aspartyl- glutamyl- valyl- aspartyl- amino- 4- methylcoumarinIBA
08/2003
1Enzyme Precursors (Zymogens)IBA
08/2003
1Caspase 8 (Caspase-8)IBA
08/2003

Therapy/Procedure

1Therapeutics
12/2009